Endosomal signalling via exosome surface TGFβ-1
Identifieur interne : 000842 ( Main/Exploration ); précédent : 000841; suivant : 000843Endosomal signalling via exosome surface TGFβ-1
Auteurs : Ganesh Vilas Shelke [Suède] ; Yanan Yin [Suède, République populaire de Chine] ; Su Chul Jang [Suède] ; Cecilia L Sser [Suède] ; Stefan Wennmalm [Suède] ; Hans Jürgen Hoffmann [Danemark] ; Li Li [République populaire de Chine] ; Yong Song Gho [Corée du Sud] ; Jonas Andreas Nilsson [Suède] ; Jan Lötvall [Suède]Source :
- Journal of Extracellular Vesicles [ 2001-3078 ] ; 2019.
Abstract
Extracellular vesicles such as exosomes convey biological messages between cells, either by surface-to-surface interaction or by shuttling of bioactive molecules to a recipient cell’s cytoplasm. Here we show that exosomes released by mast cells harbour both active and latent transforming growth factor β-1 (TGFβ-1) on their surfaces. The latent form of TGFβ-1 is associated with the exosomes via heparinase-II and pH-sensitive elements. These vesicles traffic to the endocytic compartment of recipient human mesenchymal stem cells (MSCs) within 60 min of exposure. Further, the exosomes-associated TGFβ-1 is retained within the endosomal compartments at the time of signalling, which results in prolonged cellular signalling compared to free-TGFβ-1. These exosomes induce a migratory phenotype in primary MSCs involving SMAD-dependent pathways. Our results show that mast cell-derived exosomes are decorated with latent TGFβ-1 and are retained in recipient MSC endosomes, influencing recipient cell migratory phenotype. We conclude that exosomes can convey signalling within endosomes by delivering bioactive surface ligands to this intracellular compartment.
Url:
DOI: 10.1080/20013078.2019.1650458
PubMed: 31595182
PubMed Central: 6764367
Affiliations:
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strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, Li" sort="Li, Li" uniqKey="Li L" first="Li" last="Li">Li Li</name><affiliation wicri:level="1"><nlm:aff id="AFF0007"><institution>Department of Laboratory Medicine, Shanghai First People’s Hospital, Shanghai JiaoTong University</institution>, Shanghai,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gho, Yong Song" sort="Gho, Yong Song" uniqKey="Gho Y" first="Yong Song" last="Gho">Yong Song Gho</name><affiliation wicri:level="1"><nlm:aff id="AFF0008"><institution>Department of Life Sciences, Pohang University of Science and Technology</institution>, Pohang,<country>Republic of Korea</country></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name 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xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yin, Yanan" sort="Yin, Yanan" uniqKey="Yin Y" first="Yanan" last="Yin">Yanan Yin</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Krefting Research Centre, Institute of Medicine, the Sahlgrenska Academy, University of Gothenburg</institution>, Gothenburg,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF0003"><institution>Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University, School of Medicine</institution>, Shanghai,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jang, Su Chul" sort="Jang, Su Chul" uniqKey="Jang S" first="Su Chul" last="Jang">Su Chul Jang</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Krefting Research Centre, Institute of Medicine, the Sahlgrenska Academy, University of Gothenburg</institution>, Gothenburg,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="L Sser, Cecilia" sort="L Sser, Cecilia" uniqKey="L Sser C" first="Cecilia" last="L Sser">Cecilia L Sser</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Krefting Research Centre, Institute of Medicine, the Sahlgrenska Academy, University of Gothenburg</institution>, Gothenburg,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wennmalm, Stefan" sort="Wennmalm, Stefan" uniqKey="Wennmalm S" first="Stefan" last="Wennmalm">Stefan Wennmalm</name><affiliation wicri:level="1"><nlm:aff id="AFF0004"><institution>Royal Institute of Technology-KTH, Department of Applied Physics, Experimental Biomolecular Physics Group, SciLife Laboratory</institution>, Solna,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hoffmann, Hans Jurgen" sort="Hoffmann, Hans Jurgen" uniqKey="Hoffmann H" first="Hans Jürgen" last="Hoffmann">Hans Jürgen Hoffmann</name><affiliation wicri:level="1"><nlm:aff id="AFF0005"><institution>Department of Clinical Medicine, Aarhus University</institution>, Aarhus,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AFF0006"><institution>Department of respiratory and Allergy, Aarhus University Hospital</institution>, Aarhus,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Li, Li" sort="Li, Li" uniqKey="Li L" first="Li" last="Li">Li Li</name><affiliation wicri:level="1"><nlm:aff id="AFF0007"><institution>Department of Laboratory Medicine, Shanghai First People’s Hospital, Shanghai JiaoTong University</institution>, Shanghai,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gho, Yong Song" sort="Gho, Yong Song" uniqKey="Gho Y" first="Yong Song" last="Gho">Yong Song Gho</name><affiliation wicri:level="1"><nlm:aff id="AFF0008"><institution>Department of Life Sciences, Pohang University of Science and Technology</institution>, Pohang,<country>Republic of Korea</country></nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nilsson, Jonas Andreas" sort="Nilsson, Jonas Andreas" uniqKey="Nilsson J" first="Jonas Andreas" last="Nilsson">Jonas Andreas Nilsson</name><affiliation wicri:level="1"><nlm:aff id="AFF0002"><institution>Department of Surgery, Institute of Clinical Sciences, the Sahlgrenska Academy, University of Gothenburg</institution>, Gothenburg,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lotvall, Jan" sort="Lotvall, Jan" uniqKey="Lotvall J" first="Jan" last="Lötvall">Jan Lötvall</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Krefting Research Centre, Institute of Medicine, the Sahlgrenska Academy, University of Gothenburg</institution>, Gothenburg,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of Extracellular Vesicles</title><idno type="eISSN">2001-3078</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>ABSTRACT</title><p>Extracellular vesicles such as exosomes convey biological messages between cells, either by surface-to-surface interaction or by shuttling of bioactive molecules to a recipient cell’s cytoplasm. Here we show that exosomes released by mast cells harbour both active and latent transforming growth factor β-1 (TGFβ-1) on their surfaces. The latent form of TGFβ-1 is associated with the exosomes via heparinase-II and pH-sensitive elements. These vesicles traffic to the endocytic compartment of recipient human mesenchymal stem cells (MSCs) within 60 min of exposure. Further, the exosomes-associated TGFβ-1 is retained within the endosomal compartments at the time of signalling, which results in prolonged cellular signalling compared to free-TGFβ-1. These exosomes induce a migratory phenotype in primary MSCs involving SMAD-dependent pathways. Our results show that mast cell-derived exosomes are decorated with latent TGFβ-1 and are retained in recipient MSC endosomes, influencing recipient cell migratory phenotype. We conclude that exosomes can convey signalling within endosomes by delivering bioactive surface ligands to this intracellular compartment.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Valadi, H" uniqKey="Valadi H">H Valadi</name></author><author><name sortKey="Ekstrom, K" uniqKey="Ekstrom K">K Ekström</name></author><author><name sortKey="Bossios, A" uniqKey="Bossios A">A Bossios</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lasser, C" uniqKey="Lasser C">C Lasser</name></author><author><name sortKey="Shelke, Gv" uniqKey="Shelke G">GV Shelke</name></author><author><name sortKey="Yeri, A" uniqKey="Yeri A">A Yeri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xiao, H" uniqKey="Xiao H">H Xiao</name></author><author><name sortKey="Fortin, C" uniqKey="Fortin C">C Fortin</name></author><author><name sortKey="Garneau, H" uniqKey="Garneau H">H Garneau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shelke, Gv" uniqKey="Shelke G">GV Shelke</name></author><author><name sortKey="Jang, S" uniqKey="Jang S">S Jang</name></author><author><name sortKey="Yin, Y" uniqKey="Yin Y">Y Yin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taipale, J" uniqKey="Taipale J">J Taipale</name></author><author><name sortKey="Miyazono, K" uniqKey="Miyazono K">K Miyazono</name></author><author><name sortKey="Heldin, Ch" uniqKey="Heldin C">CH Heldin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dinarello, Ca" uniqKey="Dinarello C">CA Dinarello</name></author><author><name sortKey="Margolis, Nh" uniqKey="Margolis N">NH. Margolis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Afonina, Is" uniqKey="Afonina I">IS Afonina</name></author><author><name sortKey="Muller, C" uniqKey="Muller C">C Muller</name></author><author><name sortKey="Martin, Sj" uniqKey="Martin S">SJ Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gleizes, Pe" uniqKey="Gleizes P">PE Gleizes</name></author><author><name sortKey="Munger, Js" uniqKey="Munger J">JS Munger</name></author><author><name sortKey="Nunes, I" uniqKey="Nunes I">I Nunes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khan, Sa" uniqKey="Khan S">SA Khan</name></author><author><name sortKey="Joyce, J" uniqKey="Joyce J">J Joyce</name></author><author><name sortKey="Tsuda, T" uniqKey="Tsuda T">T Tsuda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heldin, Ch" uniqKey="Heldin C">CH Heldin</name></author><author><name sortKey="Miyazono, K" uniqKey="Miyazono K">K Miyazono</name></author><author><name sortKey="Ten Dijke, P" uniqKey="Ten Dijke P">P Ten Dijke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Ye" uniqKey="Zhang Y">YE Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Derynck, R" uniqKey="Derynck R">R Derynck</name></author><author><name sortKey="Zhang, Ye" uniqKey="Zhang Y">YE Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Webber, J" uniqKey="Webber J">J Webber</name></author><author><name sortKey="Steadman, R" uniqKey="Steadman R">R Steadman</name></author><author><name sortKey="Mason, Md" uniqKey="Mason M">MD Mason</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yen, Ey" uniqKey="Yen E">EY Yen</name></author><author><name sortKey="Miaw, Sc" uniqKey="Miaw S">SC Miaw</name></author><author><name sortKey="Yu, Js" uniqKey="Yu J">JS Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gonzalez Begne, M" uniqKey="Gonzalez Begne M">M Gonzalez-Begne</name></author><author><name sortKey="Lu, B" uniqKey="Lu B">B Lu</name></author><author><name sortKey="Han, X" uniqKey="Han X">X Han</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lazar, I" uniqKey="Lazar I">I Lazar</name></author><author><name sortKey="Clement, E" uniqKey="Clement E">E Clement</name></author><author><name sortKey="Ducoux Petit, M" uniqKey="Ducoux Petit M">M Ducoux-Petit</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lim, Jw" uniqKey="Lim J">JW Lim</name></author><author><name sortKey="Mathias, Ra" uniqKey="Mathias R">RA Mathias</name></author><author><name sortKey="Kapp, Ea" uniqKey="Kapp E">EA Kapp</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Skogberg, G" uniqKey="Skogberg G">G Skogberg</name></author><author><name sortKey="Gudmundsdottir, J" uniqKey="Gudmundsdottir J">J Gudmundsdottir</name></author><author><name sortKey="Van Der Post, S" uniqKey="Van Der Post S">S van der Post</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Savukinas, Ub" uniqKey="Savukinas U">UB Savukinas</name></author><author><name sortKey="Enes, Sr" uniqKey="Enes S">SR Enes</name></author><author><name sortKey="Sjoland, Aa" uniqKey="Sjoland A">AA Sjoland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aggarwal, S" uniqKey="Aggarwal S">S Aggarwal</name></author><author><name sortKey="Pittenger, Mf" uniqKey="Pittenger M">MF Pittenger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Redis, Rs" uniqKey="Redis R">RS Redis</name></author><author><name sortKey="Calin, S" uniqKey="Calin S">S Calin</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chamberlain, G" uniqKey="Chamberlain G">G Chamberlain</name></author><author><name sortKey="Fox, J" uniqKey="Fox J">J Fox</name></author><author><name sortKey="Ashton, B" uniqKey="Ashton B">B Ashton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Caplan, Ai" uniqKey="Caplan A">AI Caplan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sargent, A" uniqKey="Sargent A">A Sargent</name></author><author><name sortKey="Miller, Rh" uniqKey="Miller R">RH Miller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garnier, D" uniqKey="Garnier D">D Garnier</name></author><author><name sortKey="Magnus, N" uniqKey="Magnus N">N Magnus</name></author><author><name sortKey="Lee, Th" uniqKey="Lee T">TH Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Refaeli, Y" uniqKey="Refaeli Y">Y Refaeli</name></author><author><name sortKey="Bhoumik, A" uniqKey="Bhoumik A">A Bhoumik</name></author><author><name sortKey="Roop, Dr" uniqKey="Roop D">DR Roop</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andres, Jl" uniqKey="Andres J">JL Andres</name></author><author><name sortKey="Ronnstrand, L" uniqKey="Ronnstrand L">L Ronnstrand</name></author><author><name sortKey="Cheifetz, S" uniqKey="Cheifetz S">S Cheifetz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Q" uniqKey="Chen Q">Q Chen</name></author><author><name sortKey="Sivakumar, P" uniqKey="Sivakumar P">P Sivakumar</name></author><author><name sortKey="Barley, C" uniqKey="Barley C">C Barley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Friand, V" uniqKey="Friand V">V Friand</name></author><author><name sortKey="David, G" uniqKey="David G">G David</name></author><author><name sortKey="Zimmermann, P" uniqKey="Zimmermann P">P Zimmermann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Melo, Sa" uniqKey="Melo S">SA Melo</name></author><author><name sortKey="Luecke, Lb" uniqKey="Luecke L">LB Luecke</name></author><author><name sortKey="Kahlert, C" uniqKey="Kahlert C">C Kahlert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wen, C" uniqKey="Wen C">C Wen</name></author><author><name sortKey="Seeger, Rc" uniqKey="Seeger R">RC Seeger</name></author><author><name sortKey="Fabbri, M" uniqKey="Fabbri M">M Fabbri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Skokos, D" uniqKey="Skokos D">D Skokos</name></author><author><name sortKey="Botros, Hg" uniqKey="Botros H">HG Botros</name></author><author><name sortKey="Demeure, C" uniqKey="Demeure C">C Demeure</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ponte, Al" uniqKey="Ponte A">AL Ponte</name></author><author><name sortKey="Marais, E" uniqKey="Marais E">E Marais</name></author><author><name sortKey="Gallay, N" uniqKey="Gallay N">N Gallay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tang, Y" uniqKey="Tang Y">Y Tang</name></author><author><name sortKey="Wu, X" uniqKey="Wu X">X Wu</name></author><author><name sortKey="Lei, W" uniqKey="Lei W">W Lei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kretzschmar, M" uniqKey="Kretzschmar M">M Kretzschmar</name></author><author><name sortKey="Massague, J" uniqKey="Massague J">J Massague</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, P" uniqKey="Gao P">P Gao</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author><author><name sortKey="Xian, L" uniqKey="Xian L">L Xian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Obberghen Schilling, E" uniqKey="Van Obberghen Schilling E">E Van Obberghen-Schilling</name></author><author><name sortKey="Roche, Ns" uniqKey="Roche N">NS Roche</name></author><author><name sortKey="Flanders, Kc" uniqKey="Flanders K">KC Flanders</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmierer, B" uniqKey="Schmierer B">B Schmierer</name></author><author><name sortKey="Hill, Cs" uniqKey="Hill C">CS Hill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Massague, J" uniqKey="Massague J">J Massague</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hao, X" uniqKey="Hao X">X Hao</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Ren, F" uniqKey="Ren F">F Ren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gross, Jc" uniqKey="Gross J">JC Gross</name></author><author><name sortKey="Chaudhary, V" uniqKey="Chaudhary V">V Chaudhary</name></author><author><name sortKey="Bartscherer, K" uniqKey="Bartscherer K">K Bartscherer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Atay, S" uniqKey="Atay S">S Atay</name></author><author><name sortKey="Banskota, S" uniqKey="Banskota S">S Banskota</name></author><author><name sortKey="Crow, J" uniqKey="Crow J">J Crow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Dk" uniqKey="Kim D">DK Kim</name></author><author><name sortKey="Cho, Y E" uniqKey="Cho Y">Y-E Cho</name></author><author><name sortKey="Komarow, Hd" uniqKey="Komarow H">HD Komarow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weiss, Dj" uniqKey="Weiss D">DJ Weiss</name></author><author><name sortKey="Chambers, D" uniqKey="Chambers D">D Chambers</name></author><author><name sortKey="Giangreco, A" uniqKey="Giangreco A">A Giangreco</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, L" uniqKey="Huang L">L Huang</name></author><author><name sortKey="Jin, R" uniqKey="Jin R">R Jin</name></author><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Hm" uniqKey="Lee H">HM Lee</name></author><author><name sortKey="Choi, E J" uniqKey="Choi E">E-J Choi</name></author><author><name sortKey="Kim, Jh" uniqKey="Kim J">JH Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Massague, J" uniqKey="Massague J">J Massague</name></author><author><name sortKey="Kelly, B" uniqKey="Kelly B">B Kelly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Di Guglielmo, Gm" uniqKey="Di Guglielmo G">GM Di Guglielmo</name></author><author><name sortKey="Le Roy, C" uniqKey="Le Roy C">C Le Roy</name></author><author><name sortKey="Goodfellow, Af" uniqKey="Goodfellow A">AF Goodfellow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Languino, Lr" uniqKey="Languino L">LR Languino</name></author><author><name sortKey="Singh, A" uniqKey="Singh A">A Singh</name></author><author><name sortKey="Prisco, M" uniqKey="Prisco M">M Prisco</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mulcahy, La" uniqKey="Mulcahy L">LA Mulcahy</name></author><author><name sortKey="Pink, Rc" uniqKey="Pink R">RC Pink</name></author><author><name sortKey="Carter, Dr" uniqKey="Carter D">DR Carter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Dongen, Hm" uniqKey="Van Dongen H">HM van Dongen</name></author><author><name sortKey="Masoumi, N" uniqKey="Masoumi N">N Masoumi</name></author><author><name sortKey="Witwer, Kw" uniqKey="Witwer K">KW Witwer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tian, T" uniqKey="Tian T">T Tian</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ge, Xn" uniqKey="Ge X">XN Ge</name></author><author><name sortKey="Ha, Sg" uniqKey="Ha S">SG Ha</name></author><author><name sortKey="Rao, A" uniqKey="Rao A">A Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Christianson, Hc" uniqKey="Christianson H">HC Christianson</name></author><author><name sortKey="Svensson, Kj" uniqKey="Svensson K">KJ Svensson</name></author><author><name sortKey="Van Kuppevelt, Th" uniqKey="Van Kuppevelt T">TH van Kuppevelt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ronnberg, E" uniqKey="Ronnberg E">E Ronnberg</name></author><author><name sortKey="Melo, Fr" uniqKey="Melo F">FR Melo</name></author><author><name sortKey="Pejler, G" uniqKey="Pejler G">G Pejler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Metcalfe, Dd" uniqKey="Metcalfe D">DD Metcalfe</name></author><author><name sortKey="Lewis, Ra" uniqKey="Lewis R">RA Lewis</name></author><author><name sortKey="Silbert, Je" uniqKey="Silbert J">JE Silbert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shelke, Gv" uniqKey="Shelke G">GV Shelke</name></author><author><name sortKey="Lasser, C" uniqKey="Lasser C">C Lasser</name></author><author><name sortKey="Gho, Ys" uniqKey="Gho Y">YS Gho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holm, M" uniqKey="Holm M">M Holm</name></author><author><name sortKey="Andersen, Hb" uniqKey="Andersen H">HB Andersen</name></author><author><name sortKey="Hetland, Te" uniqKey="Hetland T">TE Hetland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wisniewski, Jr" uniqKey="Wisniewski J">JR Wisniewski</name></author><author><name sortKey="Zougman, A" uniqKey="Zougman A">A Zougman</name></author><author><name sortKey="Nagaraj, N" uniqKey="Nagaraj N">N Nagaraj</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dominici, M" uniqKey="Dominici M">M Dominici</name></author><author><name sortKey="Le Blanc, K" uniqKey="Le Blanc K">K Le Blanc</name></author><author><name sortKey="Mueller, I" uniqKey="Mueller I">I Mueller</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li><li>Danemark</li><li>République populaire de Chine</li><li>Suède</li></country></list><tree><country name="Suède"><noRegion><name sortKey="Shelke, Ganesh Vilas" sort="Shelke, Ganesh Vilas" uniqKey="Shelke G" first="Ganesh Vilas" last="Shelke">Ganesh Vilas Shelke</name></noRegion><name sortKey="Jang, Su Chul" sort="Jang, Su Chul" uniqKey="Jang S" first="Su Chul" last="Jang">Su Chul Jang</name><name sortKey="L Sser, Cecilia" sort="L Sser, Cecilia" uniqKey="L Sser C" first="Cecilia" last="L Sser">Cecilia L Sser</name><name sortKey="Lotvall, Jan" sort="Lotvall, Jan" uniqKey="Lotvall J" first="Jan" last="Lötvall">Jan Lötvall</name><name sortKey="Nilsson, Jonas Andreas" sort="Nilsson, Jonas Andreas" uniqKey="Nilsson J" first="Jonas Andreas" last="Nilsson">Jonas Andreas Nilsson</name><name sortKey="Shelke, Ganesh Vilas" sort="Shelke, Ganesh Vilas" uniqKey="Shelke G" first="Ganesh Vilas" last="Shelke">Ganesh Vilas Shelke</name><name sortKey="Wennmalm, Stefan" sort="Wennmalm, Stefan" uniqKey="Wennmalm S" first="Stefan" last="Wennmalm">Stefan Wennmalm</name><name sortKey="Yin, Yanan" sort="Yin, Yanan" uniqKey="Yin Y" first="Yanan" last="Yin">Yanan Yin</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Yin, Yanan" sort="Yin, Yanan" uniqKey="Yin Y" first="Yanan" last="Yin">Yanan Yin</name></noRegion><name sortKey="Li, Li" sort="Li, Li" uniqKey="Li L" first="Li" last="Li">Li Li</name></country><country name="Danemark"><noRegion><name sortKey="Hoffmann, Hans Jurgen" sort="Hoffmann, Hans Jurgen" uniqKey="Hoffmann H" first="Hans Jürgen" last="Hoffmann">Hans Jürgen Hoffmann</name></noRegion><name sortKey="Hoffmann, Hans Jurgen" sort="Hoffmann, Hans Jurgen" uniqKey="Hoffmann H" first="Hans Jürgen" last="Hoffmann">Hans Jürgen Hoffmann</name></country><country name="Corée du Sud"><noRegion><name sortKey="Gho, Yong Song" sort="Gho, Yong Song" uniqKey="Gho Y" first="Yong Song" last="Gho">Yong Song Gho</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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